Key publications of interest relating to our science

Title Authors Journal reference Link
The short-term bronchodilator effects of the dual PDE3 and PDE4 inhibitor RPL554 in COPD David Singh, Katharine Abbot-Banner, Thomas Bergtsson, Kenneth Newman Eur. Respir. J. 2018 Link
Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials. Lui.G Franciosi, PhD, Prof. Zuzana Diamant, MD, Katharine H Banner, PhD, Rob Zuiker, MD, Nicoletta Morelli, MD Ingrid Kamerling, PhD, Marieke L. de Kam MSc, Prof. Jacobus Burggraaf, MD, Prof. Adam.F.Cohen, MD Prof. Mario Cazzola, Et al. The Lancet Respiratory Medicine, October 25, 2013, 2600(13)70187-5 Link
Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases Katharine H. Abbott-Banner and Clive P. Page Journal Reference: Basic & Clinical Pharmacology & Toxicology Doi: 10.1111/bcpt.12209 Link
A combined Phase I/IIa study of the safety, bronchodilator and bronchoprotective effects of nebulized RPL554, a dual PDE3/4 inhibitor, in healthy subjects and asthmatics. Franciosi L, Diamant Z, Morelli N, de Kam M, Cohen A, Walker M, Page CP. Clin Transl Allergy. 2013; 3(Suppl 1): O13 Link
Safety and bronchodilator effects of nebulized RPL554, a novel dual PDE3/4 inhibitor in COPD. Cazzola M, Calzetta L, Segreti A, Rogliani P, Page CP. Am J Respir Crit Care Med. 2013; 187:A1497 Link
RPL554, a dual phosphodiesterase 3/4 inhibitor, relaxes human brochi and acts synergistically with muscarinic receptor antagonists. Matera MG, Calzetta L, Spina D, Page CP, Facciolo F, Cazzola M. Am J Respir Crit Care Med. 2013; 187:A1495 Link
RPL554, a a dual PDE3/4 inhibitor, is well tolerated and maintains bronchodilator activity when administered by inhalation to mild to moderate allergic asthmatics on 6 consecutive days. Franciosi L, Zuiker R, Kamerling IM, Burgraaf J, Cohen A, Walker M, Page CP. Am J Respir Crit Care Med. 2013; 187:A3875 Link
Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease. Banner KH, Press NJ. British J Pharmacol. 2009; 157(6): 892-906 Link
Pharmacology and therapeutics of bronchodilators. Cazzola M, Page CP, Calzetta L, Matera MG. Pharmacol Rev. 2012 Jul;64(3):450-504. Epub 2012 May 18. Link
Non-anticoagulant effects of heparin: an overview. Lever R, Page CP. Handb Exp Pharmacol. 2012;(207):281-305. Link

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